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Six New Yorkers juggle love, friendship, and the keenly challenging specter of adulthood. Sam Wexler (Josh Radnor) is a struggling writer who's having a particularly bad day. When a young boy gets separated from his family on the subway, Sam makes the questionable decision to bring the child (Michael Algieri) (back to his apartment and thus begins a rewarding, yet complicated, friendship. Sam's life revolves around his friends-Annie (Malin Akerman), whose self-image keeps her from commitment; Charlie and Mary Catherine (Zoe Kazan), a couple whose possible move to Los Angeles tests their relationship; and Mississippi, a cabaret singer who catches Sam's eye. Sam #2 is played by (Tony Hale)