Lurene Tuttle was a character actress, who made the transition from vaudeville to radio, and later films and television. Her most enduring impact was as one of network radio's most versatile actresses. Often appearing in fifteen shows a week, comedies, dramas, thrillers, soap operas, and crime dramas, she became known as the "First Lady of Radio".
Tuttle became interested in acting after her family moved to Southern California. She appeared in Pasadena Playhouse productions before joining the vaudeville troupe, Murphy's Comedians. By the time of the Great Depression, Tuttle had put her remarkable vocal versatility to work in radio, and within a decade she became one of the most in-demand actresses in the medium.