Jessica "Jess" Weixler is an American actress. She is best known as the lead character Dawn O'Keefe in the comedy-horror film Teeth and the comedy The Big Bad Swim. She graduated in 1999 from Atherton High School in Louisville, Kentucky, where she also attended the Walden Theatre Conservatory Program and was in The River City Players acting group and in the Chamber Singers choral group. Subsequently, Weixler, attended Juilliard. She was a participant during the first year of Bruce Brubaker's InterArts performance project at Juilliard.
In 2007 she was nominated for a Breakthrough Award at the Gotham Awards, and won the Special Jury Prize in Dramatic category For a juicy and jaw-dropping performance at the Sundance Film Festival, both for her role in Teeth. She also appeared in the TV series Law & Order: Criminal Intent. In January 2009, she was named by New York magazine as the "New Indie Queen" of the year and one of the fourteen "New Yorkers you need to know".
In 2013, she joined the cast of CBS series The Good Wife, playing investigator Robyn Burdine.