Eugene Domingo is a Filipino film and theater actress, comedienne and host. She has performed in lead and supporting roles and in various genres of the film industry. She was popularly known as side-kick of the Philippines Queen of Comedy, Ai-Ai delas Alas in the Ang Tanging Ina series, until she was launched on her very first lead role in Kimmy Dora: Kambal sa Kiyeme which eventually got a sequel in 2012.
Domingo's other notable films include Bahay Kubo wherein she was awarded on her first "Best Supporting Actress" award. Her most successful film to date is the Cinemalaya entry, Ang Babae Sa Septic Tank which holds the record for the highest grossing independent film in Filipino entertainment history. The film was an official entry for various international film festivals in Vancouver, South Korea, Hawaii, Japan, and Italy. The film was also chosen by the Film Academy of the Philippines to represent the Philippines in the Best Foreign Language Film category of the 84th Academy Awards. Domingo achieved "Best Actress" awards, at the Cinemalaya and 10th Gawad Tanglaw for Films.